Document 0001
 DOCN  M9480001
 TI    Immunohistochemical characterization of inflammatory cells and
       immunologic activation markers in muscle and nerve biopsy specimens from
       patients with systemic polyarteritis nodosa.
 DT    9410
 AU    Cid MC; Grau JM; Casademont J; Campo E; Coll-Vinent B; Lopez-Soto A;
       Ingelmo M; Urbano-Marquez A; Hospital Clinic i Provincial, University of
       Barcelona, Spain.
 SO    Arthritis Rheum. 1994 Jul;37(7):1055-61. Unique Identifier : AIDSLINE
       MED/94296454
 AB    OBJECTIVE. To investigate the phenotype of infiltrating cells in classic
       lesions of polyarteritis nodosa (PAN). METHODS. Twenty-one muscle and 10
       sural nerve biopsy samples from 24 patients with systemic PAN were
       studied using avidin-biotin-peroxidase and alkaline
       phosphatase-anti-alkaline phosphatase immunohistochemical techniques.
       RESULTS. The inflammatory infiltrates consisted mainly of macrophages
       (41%) and T lymphocytes (41%), particularly of the CD4+ subset.
       Granulocytes were present in varying quantities (0-45%) and were more
       abundant in heavily infiltrated vessels and in those with fibrinoid
       necrosis. Dendritic cells could be identified in 4 samples.
       Proliferating and interleukin-2 receptor-expressing cells, present in
       71% and 79% of the patients, respectively, were more frequent in
       untreated patients. CONCLUSION. T cell-mediated immune mechanisms may
       play a role in the development and perpetuation of PAN lesions.
 DE    Adult  Aged  Biopsy  CD4-CD8 Ratio  Female
       Granulocytes/CHEMISTRY/IMMUNOLOGY/PATHOLOGY  Histocompatibility Antigens
       Class II/ANALYSIS  Human  Immunohistochemistry
       Macrophages/CHEMISTRY/IMMUNOLOGY/PATHOLOGY  Male  Middle Age
       Muscles/*PATHOLOGY  Nerve Tissue/*PATHOLOGY  Periarteritis
       Nodosa/*ETIOLOGY/IMMUNOLOGY/*PATHOLOGY  Phenotype  Receptors,
       Interleukin-2/ANALYSIS  Support, Non-U.S. Gov't
       T-Lymphocytes/CHEMISTRY/IMMUNOLOGY/PATHOLOGY  T4
       Lymphocytes/CHEMISTRY/IMMUNOLOGY/PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).